I've driven from Central Kentucky to the OBX in North Carolina in my YJ. Never thought twice about it. FYI, Lexington, KY to Ocracoke Island is about 700 miles one way.
Was it the most comfortable ride ever? Nope. Would I do it again? Yes. Of course, I'm not running eight inches of lift either, so I don't know how road worthy you are. I'm more around 5.25".