10" wide wheels aren't terrible but they don't allow for as much protection for the bead of the tire to stay put when aired down on the trail.
And just as my personal experience, I would go with more backspacing (lower numerical number so like 4 instead of 4.5). I have 33x12.50" MT/r's w/kevlar and they rub slightly with 4.25" bs. However, that is my jeep and that could be a result of not having the axle perfectly aligned with the center of the jeep. Every jeep is different. But I do believe that most people will say that 4.5" bs is not enough for 12.50" wide tires.