Bottom Line Up Front: Be completely honest with yourself about what you intend to do with your Jeep, and let that drive (pun intended) your purchase.
I've had Nitto Trail Grapplers for the past 20k miles and I absolutely love them, and for 20k miles, they still have quite deep tread remaining. They are big, rough, and tough, and they have the look to go along with them. I love the extra width and stance they give to a Wrangler, makes it look like I always picture it in my dreams
Excellent for general trail riding as well but they shine in the mud and climbing bigger obstacles (I have 35" tires). And for how aggressive they are, they are very quiet during normal driving.
That said, they are HEAVY, no doubt about it, and depending on what size you are thinking of going up to you may need to consider an aftermarket rear tire carrier if you plan on keeping a spare on the back (I will say though that mine has caused no issues thus far - apparently the stock carrier is rated to hold a 35" tire, but the Trail Grapplers are one of the heaviest 35" tires out there, so you may have an issue and I may just be an anomaly. Fair warning). And because they live up to their reputation, they also demand some decent coinage. In terms of highway driving, I have had several occasions where it is easy to get pulled due to some odd lines on the side of the highway, or collections of rain water during heavy rains. I would also say its hard to fully attribute highway handling to tires, because the quality/height of a lift (especially on a 2 door) can also change highway controllability.
If I was 20k miles in the past, I would tell myself to be brutally honest with my intentions for my Jeep. My desire was to be able to go wheel all over the coolest trails and sling mud with my buddies. Realistically, my Wrangler goes offroad a few times a year and its usually just a gas-hog grocery carrier and work transporter. Had I considered it more, I think I would have done exactly what the poster above me recommended - going with Goodyear Duratracs. Still great tires, just a little more wallet friendly and lighter.
SUMMARY: Great tire, especially for offroading, and look fantastic. For the occasional weekend warrior, get Duratracs or a different lighter tire to save money both in the purchase and MPG (unless you just have money to spend or have more vehicles to play with).