I have an 08 with 35's and 321's and a six speed. I've learned to shift and pay attention to the terrain and I do fine. I would like to regear but it is cost prohibitive right now.
If you have 3.21 gears, 35's will kill your road power, especially in the case of passing on the freeway, climbing even modest hills, and headwinds. Yup. Headwinds.